Spring break (mid March - mid April) destinations by vibe: PARTY: 1) Miami Beach FL, 2) South Padre Island TX, 3) Panama City Beach FL, 4) Cabo San Lucas Mexico (passport needed). FAMILY: 5) Orlando FL (Disney/Universal), 6) San Diego CA (zoo, beaches, weather), 7) Lake Tahoe (ski + spring snow), 8) Williamsburg VA (historic + Busch Gardens). ROMANTIC/QUIET: 9) Sedona AZ (red rocks, spas), 10) Key West FL (quirky charm). NATURE: Grand Canyon, Zion, Yosemite. Tips: book 60-90 days ahead for major destinations, expect 30-50% premium pricing. Less crowded alternative weeks: late March (before college spring break peak) or early April.